1b3u Cytosolic signaling Protein Phosphatase 2A regulatory subunit from human. 3h7x Bacterial adhesion Part of adhesin from Yersinia enterocolitica. 1xu9 Steroid metabolism Enzyme interconverting cortisone and cortisol from human. Mimic of a protein in eukaryotic defence. 4u48 Protease inhibitor α2-macroglobulin from Salmonella. From electron crystallography of 2D array. 3j04 Muscle contraction Myosin fragment bound to regulatory chains, from chicken. 2q5r Milk sugar metabolism Tagatose-6-phosphate kinase from Staphylococcus aureus. surface proteins Non-pore subunits cut from the image. 4j3o Pore to export Usher pore (24-stranded β-barrel ) in outer membrane of E. Ribonuclease will bind in centre super-tight. 2qyc Unknown Ferredoxin -like protein from Bordetella bronchiseptica 2bnh Blocks RNA degradation Ribonuclease inhibitor from pig. PDB code Function Comments 3ifz DNA topology DNA gyrase reaction core from M. Hyperlinks on the right are helpful background. Movie as mp4 (14 MB) or avi (20 MB) Table of the protein alphabet Click on the PDB code to go to the primary research paper. pse files 15 MB) for viewing 3D structures with PyMOL software. All individual protein letters ( Zip of. xcf ( Zip file 9MB) for more control using the freeware GNU Image Manipulation Program. Just type in to spell out words in Protein Alphabet- converter on webpage from NIH - Complete protein alphabet image (as above) Low resolution (tif, 1MB) Low res jpg, High resolution (tif, 10MB) - Editable protein alphabet image so easy to re-arrange letters in PowerPoint, or as. Copyright on files is mine, so you don’t need journal permission. Protein alphabet resources Please use these files freely for any non-commercial purposes. Introduction to crystallography through cartoons from the Royal Institution. B, E, F, G, H, K, and R are hard to find.) Where all written alphabets came from: BBC Four - The Secret History of Writing Videos for non-scientists What is a Protein? Learn about the 3D shape and function of macromolecules. Do you know other protein structures matching well to letters or numbers? (O and C are relatively easy to find. Also, alphabets of human cell nuclei, tissues from histochemical staining, polymer lithography, or DNA self-assembly. Movie of protein alphabet rotating or watch on YouTube Can you help? - What other alphabets are there representing shapes in science? I know of one from Kjell Bloch Sandved finding the alphabet on butterfly wings. The structures are coloured with the N-terminus of each chain in blue and the C- terminus in red. These structures are shown in cartoon format, which makes the overall path of the polypeptide chain easier to see alpha-helices are shown as coils and beta-strands are shown as arrows. This alphabet was published in Nature Structural and Molecular Biology in May 2015. In the table below, I briefly describe the function of the protein and give a link to the PDB code, so you can click on that code to easily find more about any structure that interests you. It is those groups who did the hard work! When academic researchers solve a protein structure, they make the structure freely available in the Protein Data Bank (PDB), for anyone to look at and learn from. (Some of the lab’s research relates to building new protein architectures.) Note that these are not structures from my lab- they come from groups around the world. Outreach: A protein alphabet I was thinking about the diversity of protein shapes and so curated the alphabet below.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |